Regulation of metal ion recognition by allosteric effects in thiacalix[4]crown based receptors

Kumar, Manoj ; Dhir, Abhimanew ; Bhalla, Vandana (2009) Regulation of metal ion recognition by allosteric effects in thiacalix[4]crown based receptors Tetrahedron, 65 (36). pp. 7510-7515. ISSN 0040-4020

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Official URL: https://www.sciencedirect.com/science/article/pii/...

Related URL: http://dx.doi.org/10.1016/j.tet.2009.07.014

Abstract

Three new ditopic receptors 3a–c based on thiacalix[4]arene of 1,3 alternate conformation possessing two different complexation sites have been designed and synthesized for both soft and hard metal ions. The imino nitrogens bind soft metal ion (Ag+/Pb2+/Cu2+) and the crown moiety binds K+ ion. The preliminary investigations show that 3a–c behave as ditopic receptors for Ag+/K+, Pb2+/K+, and Cu2+/K+ ions, respectively. In all the three receptors it was observed that the formation of 3a·Ag+/3b·Pb2+/3c·Cu2+ complex triggers the decomplexation of K+ ion from crown moiety and acts as a gateway, which regulates the binding of alkali metal to crown moiety. Thus, allosteric binding between metal ions ‘switch off’ the recognition ability of crown ether ring.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
ID Code:114069
Deposited On:18 May 2018 08:57
Last Modified:18 May 2018 08:57

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