Three sequential C–N bond formations: tert-butyl nitrite as a n1 synthon in a three component reaction leading to imidazo[1,2-a]quinolines and imidazo[2,1-a]isoquinolines

Sau, Prasenjit ; Rakshit, Amitava ; Modi, Anju ; Behera, Ahalya ; Patel, Bhisma K. (2018) Three sequential C–N bond formations: tert-butyl nitrite as a n1 synthon in a three component reaction leading to imidazo[1,2-a]quinolines and imidazo[2,1-a]isoquinolines The Journal of Organic Chemistry, 83 (2). pp. 1056-1064. ISSN 0022-3263

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Official URL: https://pubs.acs.org/doi/abs/10.1021/acs.joc.7b028...

Related URL: http://dx.doi.org/10.1021/acs.joc.7b02815

Abstract

tert-Butyl nitrite serves the dual role of an oxidant as well as a N1 synthon in a multicomponent reaction involving quinolines, isoquinolines, and styrenes. Herein, two sp2 C–H functionalizations of styrenes and one sp2 C–H functionalization of quinolines and isoquinolines lead to the formation of fused quinolines and isoquinolines via three sequential C–N bond formations.

Item Type:Article
Source:Copyright of this article belongs to American Chemical Society.
ID Code:114029
Deposited On:02 May 2018 04:52
Last Modified:02 May 2018 04:52

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