Patel, Bhisma Kumar ; Eckstein, Fritz (1997) 5′-Deoxy-5′-thioribonucleoside-5′-triphosphates Tetrahedron Letters, 38 (6). pp. 1021-1024. ISSN 0040-4039
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Official URL: https://www.sciencedirect.com/science/article/pii/...
Related URL: http://dx.doi.org/10.1016/S0040-4039(97)00084-1
Abstract
5′-Deoxy-5′-thiouridine- and 5′-deoxy-5′-thioadenosine-5′-triphosphate 6 and 7were chemically synthesised by two methods. Their incorporation into RNA to produce a 5′-S-bridging phosphorothioate internucleotide linkages, using T7 RNA polymerase, was investigated. Reaction of P1-(S)-thiotriphosphate with 5′-iodo-5′-deoxynucleoside leads to 5′-deoxy-5′-thioribonucleoside-5′-triphosphates. Their incorporation into RNA to produce a 5′-S-bridging phosphorothioate internucleotide linkage, using T7 RNA polymerase, was investigated.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 113980 |
| Deposited On: | 02 May 2018 04:51 |
| Last Modified: | 02 May 2018 04:51 |
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