Naik, Sarala ; Bhattacharjya, Gitalee ; Kavala, Veerababu Rao ; Patel, Bhisma K. (2004) Mild and eco-friendly chemoselective acylation of amines in aqueous medium Arkivoc, 2004 (1). pp. 55-63. ISSN 1424-6376
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Official URL: http://www.arkat-usa.org/get-file/19432/
Related URL: http://dx.doi.org/10.3998/ark.5550190.0005.104
Abstract
Amines in the form of amine hydrochlorides are efficiently acylated with anhydrides in an aqueous medium on addition of NaHCO3. Both cyclic and acyclic anhydrides react with equal ease with an amine and amines of various stereo-electronic factors react with the same rates with an anhydride. No chromatographic separation is needed for isolation of the acylated product. Reactions in aqueous medium, innocuous by-products and chemoselective acylation of amines in the presence of phenols and thiols have been achieved with high selectivity.
| Item Type: | Article |
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| Source: | Copyright of this article belongs to Arkat USA Inc. |
| Keywords: | Amines; Amides; Acylation; Anhydrides; Aqueous Medium; Chemoselective |
| ID Code: | 113968 |
| Deposited On: | 02 May 2018 04:56 |
| Last Modified: | 02 May 2018 04:56 |
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