Banerjee, Arghya ; Bera, Anupam ; Guin, Srimanta ; Rout, Saroj Kumar ; Patel, Bhisma K. (2013) Regioselective ortho-hydroxylation of 2-arylbenzothiazole via substrate directed C–H activation Tetrahedron, 69 (9). pp. 2175-2183. ISSN 0040-4020
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Official URL: https://www.sciencedirect.com/science/article/pii/...
Related URL: http://dx.doi.org/10.1016/j.tet.2012.12.067
Abstract
An efficient protocol has been developed for the direct ortho-hydroxylation of 2-arylbenzothiazole using Pd(OAc)2 as the catalyst and either of DIB/AcOH or Oxone/TFA combinations under air atmosphere. Under both these conditions, the methodology tolerates a diverse array of substituents giving good to excellent yields of corresponding ortho-hydroxylated products. Regioselective hydroxylation is observed at the less sterically hindered site of the phenyl ring possessing substituents at its meta position.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Pd-catalysis; Ortho-hydroxylation; 2-Arylbenzothiazole; C–H Activation |
| ID Code: | 113884 |
| Deposited On: | 02 May 2018 04:49 |
| Last Modified: | 02 May 2018 04:49 |
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