Gurjar, Mukund K. ; Murugaiah, A. M. S. ; Srinivasa Reddy, Dandepally (2003) A new route to prepare 6-chloro-5-(2-chloroethyl)oxindole Organic Process Research & Development, 7 (3). pp. 309-312. ISSN 1083-6160
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Official URL: http://pubs.acs.org/doi/abs/10.1021/op020095k
Related URL: http://dx.doi.org/10.1021/op020095k
Abstract
6-Chloro-5-(2-chloroethyl)oxindole, a key intermediate in the manufacturing of the antipsychotic drug, ziprasidone, has been synthesized by a new route. The salient features of the synthesis are (1) bis-dialkylation of 2,4-difluoro-5-chloronitrobenzene with sodium diethyl malonate, (2) decarboxylative hydrolysis to obtain the oxindole derivative, and (3) reduction and chlorination of acetic ester side chain.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 11384 |
| Deposited On: | 09 Nov 2010 05:16 |
| Last Modified: | 02 Jun 2011 09:49 |
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