Bu4NI catalyzed C–N bond formation via cross-dehydrogenative coupling of aryl ethers (Csp3–H) and tetrazoles (N–H)

Rajamanickam, Suresh ; Majji, Ganesh ; Santra, Sourav Kumar ; Patel, Bhisma K. (2015) Bu4NI catalyzed C–N bond formation via cross-dehydrogenative coupling of aryl ethers (Csp3–H) and tetrazoles (N–H) Organic Letters, 17 (22). pp. 5586-5589. ISSN 1523-7060

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Official URL: https://pubs.acs.org/doi/abs/10.1021/acs.orglett.5...

Related URL: http://dx.doi.org/10.1021/acs.orglett.5b02749

Abstract

Intermolecular C–N bond formations via Cross-dehydrogenative Coupling (CDC) of aryl ethers and tetrazoles have been developed under a metal-free condition. In the presence of catalytic amount of Tetrabutylammonium Iodide (TBAI) and aqueous TBHP, aryl ethers coupled efficiently with tetrazoles to afford hemiaminal ethers. This strategy showed high level of regioselectivity for substrates possessing multiple sp3 C–H bonds adjacent to the ethereal oxygen.

Item Type:Article
Source:Copyright of this article belongs to American Chemical Society.
ID Code:113806
Deposited On:30 Apr 2018 12:18
Last Modified:30 Apr 2018 12:18

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