Synthesis of 2-amino-substituted-1,3,4-thiadiazoles via 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) mediated intramolecular C–S bond formation in thiosemicarbazones

Singh, Sarangthem Joychandra ; Rajamanickam, Suresh ; Gogoi, Anupal ; Patel, Bhisma K. (2016) Synthesis of 2-amino-substituted-1,3,4-thiadiazoles via 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) mediated intramolecular C–S bond formation in thiosemicarbazones Tetrahedron Letters, 57 (9). pp. 1044-1047. ISSN 0040-4039

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Official URL: https://onlinelibrary.wiley.com/doi/pdf/10.1002/ch...

Related URL: http://dx.doi.org/10.1016/j.tetlet.2016.01.083

Abstract

An intramolecular cyclization of thiosemicarbazones (I) using DDQ is developed to afford a series of 2‐amino‐substituted‐1,3,4‐thiadiazoles (II) in moderate to good yields.

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