Chowdhury, Nilanjana ; Dutta, Sansa ; Nishitha, Boda ; Dasgupta, Swagata ; Singh, N. D. Pradeep (2010) N,O-Diacyl-4-benzoyl-N-phenylhydroxylamines as photoinduced DNA cleaving agents Bioorganic & Medicinal Chemistry Letters, 20 (18). pp. 5414-5417. ISSN 0960-894X
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Official URL: https://www.sciencedirect.com/science/article/pii/...
Related URL: http://dx.doi.org/10.1016/j.bmcl.2010.07.116
Abstract
Photoinduced homolytic fission of nitrogen–oxygen bond in N,O-diacyl-4-benzoyl-N-phenylhydroxylamines using ⩾310 nm UV light for 10 min produced acylaminyl and acyloxy radicals, which resulted in single strand cleavage of DNA at pH 7.0. Further the DNA cleaving ability of N,O-diacyl-4-benzoyl-N-phenylhydroxylamines found to depend both on its concentration and acyl substituents.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Acylaminyl Radicals; DNA Cleavage; Photolysis |
| ID Code: | 113770 |
| Deposited On: | 10 May 2018 12:08 |
| Last Modified: | 10 May 2018 12:08 |
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