Siddhanta, Soumik ; Barman, Ishan ; Narayana, Chandrabhas (2015) Revealing the trehalose mediated inhibition of protein aggregation through lysozyme–silver nanoparticle interaction Soft Matter, 11 (37). pp. 7241-7249. ISSN 1744-683X
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Official URL: http://pubs.rsc.org/en/content/articlelanding/2015...
Related URL: http://dx.doi.org/10.1039/C5SM01896J
Abstract
We propose a facile and robust carbohydrate-mediated method for the prevention of nanoparticle induced denaturation and aggregation of proteins. Using label-free plasmon-enhanced Raman spectroscopy measurements, the mechanistic principles of trehalose stabilization in a model protein–nanoparticle system are elucidated for the first time, facilitating its further application in diagnostic and therapeutic nanoplex development.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Royal Society of Chemistry. |
| ID Code: | 113642 |
| Deposited On: | 23 Apr 2018 12:44 |
| Last Modified: | 23 Apr 2018 12:44 |
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