Reja, Shahi Imam ; Bhalla, Vandana ; Manchanda, Shaffi ; Kaur, Gurcharan ; Kumar, Manoj (2014) Chemodosimeter approach for nanomolar detection of Cu2+ ions and their bio-imaging in PC3 cell lines RSC Advances, 4 (82). pp. 43470-43476. ISSN 2046-2069
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Official URL: http://pubs.rsc.org/en/Content/ArticleLanding/2014...
Related URL: http://dx.doi.org/10.1039/C4RA08894H
Abstract
A new rhodamine–azaindole based receptor 4 has been synthesized which selectively senses Cu2+ ions via a fluorescence resonance energy transfer (FRET) process in acetonitrile while in mixed aqueous media it undergoes Cu2+ promoted hydrolysis among the various metal ions tested (Pb2+, Ba2+, Fe3+, Cd2+, Ag+, Zn2+, Hg2+, Cu2+, Ni2+, Co2+, Fe2+ and Mg2+). The time resolved fluorescence studies also support the Cu2+ promoted hydrolysis of receptor 4 in mixed aqueous media. The detection limit for Cu2+ ions has been found to be 20 nM. The potential biological application of probe 4 is evaluated for in vitro detection of copper ions in prostate cancer (PC3) cell lines.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Royal Society of Chemistry. |
| ID Code: | 113508 |
| Deposited On: | 16 May 2018 04:13 |
| Last Modified: | 16 May 2018 04:13 |
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