Development and sensing applications of fluorescent motifs within the mitochondrial environment

Abstract

The potential use of fluorescent molecular probes to measure ions and biomolecules has contributed incessantly to the understanding of chemical and biological systems. The approach has many advantages such as high sensitivity, simplicity and non-destructive cellular imaging that offer visible information about the targeted species. In this article, our objective is to discuss fluorescent probes that have sensing applications within the mitochondrial environment. Mitochondria are cellular organelles which are well known for their unique physiological functions and have been found to be associated with various diseases and disorders. It is therefore, important to develop new tools and tactics that can provide useful information concerning the mitochondrial environment which in turn is essential to understand its biophysical functioning and related diseases.