Chowdhury, Nilanjana ; Dasgupta, Swagata ; Pradeep Singh, N. D. (2012) Photoinduced DNA cleavage by anthracene based hydroxamic acids Bioorganic & Medicinal Chemistry Letters, 22 (14). pp. 4668-4671. ISSN 0960-894X
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Official URL: https://www.sciencedirect.com/science/article/pii/...
Related URL: http://dx.doi.org/10.1016/j.bmcl.2012.05.084
Abstract
Two different series of naphthalene and anthracene based hydroxamic acids having amino acid derivatives were synthesized. Single strand DNA cleavage was achieved on irradiation of newly synthesized hydroxamic acids by UV light (⩾350 nm). Both reactive oxygen species (ROS) and generated radicals from hydroxamic acids were shown to be responsible for the DNA cleavage. Further, DNA cleaving ability of hydroxamic acids was found to be dependent on its concentration and on its structure.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Hydroxamic Acid; DNA Cleavage; UV Light |
| ID Code: | 113390 |
| Deposited On: | 15 May 2018 11:14 |
| Last Modified: | 15 May 2018 11:14 |
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