Pandey, Nitin K. ; Ghosh, Sudeshna ; Dasgupta, Swagata (2010) Fibrillation in human serum albumin is enhanced in the presence of Copper(II) Journal of Physical Chemistry B, 114 (31). pp. 10228-10233. ISSN 1520-6106
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Official URL: https://pubs.acs.org/doi/10.1021/jp103876p
Related URL: http://dx.doi.org/10.1021/jp103876p
Abstract
The aggregation process in proteins is governed by several factors such as temperature, pH, presence of electrolytes, denaturants, and metal ions. Here, we report the role of Cu(II) in inducing rapid fibrillation in human serum albumin. We have monitored this process via UV−vis spectroscopy, fluorescence spectroscopy, circular dichroism, ζ-potential measurements, electron paramagnetic resonance studies, fluorescence microscopy, and field emission scanning electron microscopy. Images show a fibrillar network of human serum albumin in the presence of Cu(II) in 60% ethanol incubated at 65 °C at physiological pH. All other studies also support the enhanced fibrillation in presence of Cu(II).
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 113291 |
| Deposited On: | 15 May 2018 06:40 |
| Last Modified: | 15 May 2018 06:40 |
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