Venkatesh, Yarra ; Rajesh, Y. ; Karthik, S. ; Chetan, A C ; Mandal, Mahitosh ; Jana, Avijit ; Pradeep Singh, N. D. (2016) Photocaging of single and dual (similar or different) carboxylic and amino acids by acetyl carbazole and its application as dual drug delivery in cancer therapy The Journal of Organic Chemistry, 81 (22). pp. 11168-11175. ISSN 0022-3263
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Official URL: https://pubs.acs.org/doi/abs/10.1021/acs.joc.6b021...
Related URL: http://dx.doi.org/10.1021/acs.joc.6b02152
Abstract
A new Fluorescent Photoremovable Protecting Group (FPRPG) based on acetylcarbazole framework has been explored for the first time release of single and dual (similar or different) substrates from single chromophore. Mechanistic studies of the photorelease process revealed that photorelease of two (similar or different) substrates from acetyl carbazole proceeds via a stepwise pathway. Further, we constructed photoresponsive dual Drug Delivery System (DDS) to release two different anticancer drugs (caffeic acid and chlorambucil, 1 equiv each). In vitro study reveals that our DDS exhibit excellent properties like biocompatibility, cellular uptake and photoregulated dual drug release.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 113175 |
| Deposited On: | 09 May 2018 11:56 |
| Last Modified: | 09 May 2018 11:56 |
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