Garai, Kanchan ; Sureka, Ruchi ; Maiti, S. (2007) Detecting amyloid-β aggregation with fiber-based fluorescence correlation spectroscopy Biophysical Journal, 92 (7). L55-L57. ISSN 0006-3495
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Official URL: http://www.cell.com/biophysj/abstract/S0006-3495(0...
Related URL: http://dx.doi.org/10.1529/biophysj.106.101485
Abstract
Soluble aggregates critically influence the chemical and biological aspects of amyloid protein aggregation, but their population is difficult to measure, especially in vivo. We take an optical fiber-based fluorescence correlation spectroscopy (FCS) approach to characterize a solution of aggregating amyloid-β molecules. We find that this technique can easily resolve aggregate particles of size 100 nm or greater in vitro, and the size distribution of these particles agrees well with that obtained by conventional FCS techniques. We propose fiber FCS as a tool for studying aggregation in vivo.
Item Type: | Article |
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Source: | Copyright of this article belongs to Elsevier Science. |
ID Code: | 113062 |
Deposited On: | 24 May 2018 11:08 |
Last Modified: | 24 May 2018 11:08 |
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