Sharma, Shaily ; Bano, Subia ; Ghosh, Anindya S. ; Mandal, Mahitosh ; Kim, Hae-Won ; Dey, Tuli ; Kundu, Subhas. C. (2016) Silk fibroin nanoparticles support in vitro sustained antibiotic release and osteogenesis on titanium surface Nanomedicine: Nanotechnology, Biology and Medicine, 12 (5). pp. 1193-1204. ISSN 1549-9634
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Official URL: https://www.sciencedirect.com/science/article/pii/...
Related URL: http://dx.doi.org/10.1016/j.nano.2015.12.385
Abstract
Increasing amounts of metal-based implants are used for orthopedic or dental surgeries throughout the world. Still several implant-related problems such as inflammation, loosening and bacterial infection are prevalent. These problems stem from the immediate microbial contamination and failure of initial osteoblast adhesion. Additionally, bacterial infections can cause serious and life-threatening conditions such as osteomyelitis. Here, antibiotic (gentamicin)-loaded silk proteinfibroin (non-mulberry silkworm, Antheraea mylitta) nanoparticles are fabricated and deposited over the titanium surface to achieve sustained drug release in vitro and to alter the surface nano-roughness. Based on the altered surface topography, chemistry and antibacterial activity, we conclude that the nanoparticle-deposited surfaces are superior for osteoblast adhesion, proliferation and differentiation in comparison to bare Ti. This method can be utilized as a cost-effective approach in implant modification.
Item Type: | Article |
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Source: | Copyright of this article belongs to Elsevier Science. |
Keywords: | Nanoparticle; Fibroin; Titanium; Osteogenesis; Controlled Drug Release |
ID Code: | 113045 |
Deposited On: | 10 May 2018 09:41 |
Last Modified: | 10 May 2018 09:41 |
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