Konkimalla, V. Badireenath ; Chandra, Nagasuma (2003) Determinants of histamine recognition: implications for the design of antihistamines Biochemical and Biophysical Research Communications, 309 (2). pp. 425-431. ISSN 0006-291X
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Official URL: https://www.sciencedirect.com/science/article/pii/...
Related URL: http://dx.doi.org/10.1016/j.bbrc.2003.08.023
Abstract
Towards understanding how histamine, a vital neurotansmitter, can perform multiple physiological tasks, an analysis of the different proteins that bind histamine is reported here. Their structural comparison reveals conformational rigidity of histamine. Yet, flexibility in the modes of histamine binding has been observed, which appears to suit specific biological roles of the proteins. These results will be helpful in developing specific antihistamines and also in understanding the pharmacological and toxicological profiles of existing antihistamines.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Histamine; Binding Modes; Structural Comparison; Structural Determinants; Side-effects; Specific Design |
| ID Code: | 112810 |
| Deposited On: | 19 Apr 2018 06:45 |
| Last Modified: | 19 Apr 2018 06:45 |
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