Samuchiwal, Sachin Kumar ; Tousif, Sultan ; Singh, Dhiraj Kumar ; Kumar, Arun ; Ghosh, Anamika ; Bhalla, Kuhulika ; Prakash, Prem ; Kumar, Sushil ; Trivedi, Ashish Chandra ; Bhattacharyya, Maitree ; Das, Gobardhan ; Ranganathan, Anand (2014) A novel peptide interferes with Mycobacterium tuberculosis virulence and survival FEBS Open Bio, 4 (1). pp. 735-740. ISSN 2211-5463
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Official URL: http://onlinelibrary.wiley.com/doi/10.1016/j.fob.2...
Related URL: http://dx.doi.org/10.1016/j.fob.2014.08.001
Abstract
Tuberculosis (TB) is a huge global burden, with new and resistant strains emerging at an alarming rate, necessitating an urgent need for a new class of drug candidates. Here, we report that SL3, a novel 33-amino acid peptide, causes debilitating effects on mycobacterial morphology. Treatment with SL3 drastically inhibits the growth of Mycobacterium tuberculosis in vitro as well as in a pre-clinical mouse model for M.tb infection. Microarray analysis of SL3-expressing strain demonstrates wide-scale transcriptional disruption in M.tb. We therefore believe that SL3 and similar peptides may herald a new approach towards discovering new molecules for TB therapy.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to John Wiley & Sons, Inc. |
| ID Code: | 112716 |
| Deposited On: | 07 Jun 2018 04:45 |
| Last Modified: | 07 Jun 2018 04:45 |
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