Cetirizine derived supramolecular topical gel in action: Rational design, characterization and in vivo self-delivery application in treating skin allergy in mice

Majumder, Joydeb ; Deb, Jolly ; Husain, Ahmad ; Jana, Siddhartha Sankar ; Dastidar, Parthasarathi (2015) Cetirizine derived supramolecular topical gel in action: Rational design, characterization and in vivo self-delivery application in treating skin allergy in mice Journal of Materials Chemistry B, 3 (32). pp. 6634-6644. ISSN 2050-750X

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Official URL: http://pubs.rsc.org/en/content/articlelanding/2015...

Related URL: http://dx.doi.org/10.1039/C5TB00676G

Abstract

A conventional drug delivery system requires a delivery vehicle which often faces various problems such as inefficient drug loading into the delivery vehicle and its release, cytotoxicity and biodegradability of the delivery vehicle, etc., whereas a supramolecular gel based self-delivery system delivers a gelator drug at the target site without using any vehicle thereby getting rid of such problems. Here, a simple salt formation strategy has been employed to convert a well known anti-allergic drug (cetirizine) to a supramolecular gelator for the purpose of making a topical gel for in vivo self-delivery applications. The salt of cetirizine and tyramine (salt 3) displays excellent gelation properties in methylsalicylate/menthol. The gels are characterised by electron microscopy, and table top- and dynamic rheology. The gelator salt 3 displays excellent physiological stability in phosphate buffer saline (PBS) and it is biocompatible in mouse macrophage RAW 264.7 and mouse myoblast C2C12 cell lines. A methylsalicylate/menthol topical gel of salt 3 is successfully self-delivered in treating the 2,4-dinitrochlorobenzene (DNCB)-induced allergic skin condition in mice.

Item Type:Article
Source:Copyright of this article belongs to Royal Society of Chemistry.
ID Code:112698
Deposited On:19 Apr 2018 11:22
Last Modified:19 Apr 2018 11:22

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