Isoniazid induces apoptosis of activated CD4+ T cells: implications for post-therapy tuberculosis reactivation and reinfection

Tousif, Sultan ; Singh, Dhiraj Kumar ; Ahmad, Shaheer ; Moodley, Prashini ; Bhattacharyya, Maitree ; Van Kaer, Luc ; Das, Gobardhan (2014) Isoniazid induces apoptosis of activated CD4+ T cells: implications for post-therapy tuberculosis reactivation and reinfection Journal of Biological Chemistry, 289 (44). pp. 30190-30195. ISSN 0021-9258

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Official URL: http://www.jbc.org/content/289/44/30190.full

Related URL: http://dx.doi.org/10.1074/jbc.C114.598946

Abstract

Tuberculosis (TB) remains the second highest killer from a single infectious disease worldwide. Current therapy of TB is lengthy and consists of multiple expensive antibiotics, in a strategy referred to as Directly Observed Treatment, Short Course (DOTS). Although this therapy is effective, it has serious disadvantages. These therapeutic agents are toxic and are associated with the development of a variety of drug-resistant TB strains. Furthermore, patients treated with DOTS exhibit enhanced post-treatment susceptibility to TB reactivation and reinfection, suggesting therapy-related immune impairment. Here we show that Isoniazid (INH) treatment dramatically reduces Mycobacterium tuberculosis antigen-specific immune responses, induces apoptosis in activated CD4+ T cells, and renders treated animals vulnerable to TB reactivation and reinfection. Consequently, our findings suggest that TB treatment is associated with immune impairment.

Item Type:Article
Source:Copyright of this article belongs to American Society for Biochemistry and Molecular Biology.
Keywords:Bacterial Pathogenesis; Cytokine; Immunology; Interleukin; T Helper Cells
ID Code:112695
Deposited On:07 Jun 2018 04:44
Last Modified:07 Jun 2018 04:44

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