Pahuja, D. N. ; Ganatra, R. D. ; Shah, D. H. (1978) Effect of thionamides on adenyl cyclase activity and phospholipogenesis in rat thyroids Biochemical Pharmacology, 27 (4). pp. 487-489. ISSN 0006-2952
Full text not available from this repository.
Official URL: http://linkinghub.elsevier.com/retrieve/pii/000629...
Related URL: http://dx.doi.org/10.1016/0006-2952(78)90382-9
Abstract
The effects of two thionamide drugs, propylthiouracil (PTU) and methylmercaptoimidazole (MMI), are studied on adenyl cyclase (AC) activity and phospholipogenesis (PLGS), in rat thyroids. Both these manifestations of TSH-action are stimulated in the thyroids of rats fed MMI, while depressed in thyroids of rats fed PTU. Besides, induction of larger goitres in the rats fed PTU is accompanied with the lesser gain in the final body-weight after 6 weeks, when compared with the age-paired rats of MMI or control groups. There seems to exist an inverse relationship between the thyroid-weight and body-weight of rats from control, MMI and PTU groups. The differential action of these antithyroid drugs is probably due to the different endocrine status of the animals.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 11254 |
| Deposited On: | 09 Nov 2010 03:43 |
| Last Modified: | 01 Jun 2011 12:15 |
Repository Staff Only: item control page
