Michael Garavito, R. ; DeWitt, David L. (1999) The cyclooxygenase isoforms: structural insights into the conversion of arachidonic acid to prostaglandins Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1441 (2-3). pp. 278-287. ISSN 1388-1981
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/S1388-1981(99)00147-X
Abstract
Despite the marked differences in their physiological roles, the structures and catalytic functions of the cyclooxygenase isozymes COX-1 and -2 are virtually identical. Nevertheless, a handful of amino acid substitutions give rise to subtle differences in ligand binding between the two isoforms. These ‘small’ alterations of isozyme structure are sufficient to allow the design of new, isoform-selective drugs.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Cyclooxygenase; Membrane Protein; Aspirin; Prostaglandin Biosynthesis |
| ID Code: | 111920 |
| Deposited On: | 18 Sep 2017 12:25 |
| Last Modified: | 18 Sep 2017 12:25 |
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