Gene copy number alteration profile and its clinical correlation in B-cell acute lymphoblastic leukemia

Gupta, Sanjeev Kumar ; Bakhshi, Sameer ; Kumar, Lalit ; Kamal, Vineet Kumar ; Kumar, Rajive (2017) Gene copy number alteration profile and its clinical correlation in B-cell acute lymphoblastic leukemia Leukemia and Lymphoma, 58 (2). pp. 333-342. ISSN 1042-8194

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Official URL: http://www.tandfonline.com/doi/abs/10.1080/1042819...

Related URL: http://dx.doi.org/10.1080/10428194.2016.1193855

Abstract

The genes related to B-cell development are frequently altered in B-cell acute lymphoblastic leukemia (B-ALL). One hundred sixty-two newly diagnosed B-ALL cases, median age 8.5 years (2 months–67 years), were prospectively analyzed for copy number alterations (CNAs) in CDKN2A/B, IKZF1, PAX5, RB1, ETV6, BTG1, EBF1, and pseudoautosomal region genes (CRLF2, CSF2RA, IL3RA) using multiplex ligation-dependent probe amplification. The CNAs were detected in 114 (70.4%) cases; most commonly affected genes being CDKN2A/B-55 (34%), PAX5-51 (31.5%), and IKZF1-43 (26.5%). IKZF1 and RB1 deletions correlated with higher induction failure. Patients classified as good-risk, according to the integrated CNA profile and cytogenetic criteria, had lower induction failure [5 (8.6%) vs. 20 (25.3%); p = 0.012]. Those classified as good-risk, based on CNA profile irrespective of cytogenetics, also showed lower induction failure [6 (9.4%) vs. 19 (26%); p = 0.012]. The CNA profile identified patients with better induction outcome and has a potential role in better risk stratification of B-ALL.

Item Type:Article
Source:Copyright of this article belongs to Taylor & Francis Group.
Keywords:B-ALL Genetics; Copy Number Variations in ALL; MLPA in B-ALL; Mutations in Acute Leukemia
ID Code:111310
Deposited On:25 Sep 2017 12:42
Last Modified:25 Sep 2017 12:42

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