De, Soumita ; Maroo, Niteeka ; Saha, Piu ; Hazra, Samik ; Chatterjee, Mitali (2013) Ethanolic extract of Piper betle Linn. leaves reduces nociception via modulation of arachidonic acid pathway Indian Journal of Pharmacology, 45 (5). pp. 479-482. ISSN 0253-7613
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Official URL: http://www.ijp-online.com/article.asp?issn=0253-76...
Related URL: http://dx.doi.org/10.4103/0253-7613.117766
Abstract
Objectives: The objective of this study was to evaluate the peripheral analgesic effect of Piper betle leaf extract (PBE) along with establishing its putative mechanism of action. Materials and Methods: Male Swiss albino mice after pre-treatment (1 h) with different doses of PBE were injected 0.8% (v/v) acetic acid i.p.; the onset and number of writhes were noted up to 15 min. To evaluate the mechanism of action, the murine peritoneal exudate was incubated with PBE for 1 h, followed by exposure to arachidonic acid (AA) and generation of reactive oxygen species (ROS) was measured by flow cytometry using 2',7'-dichlorodihydrofluorescein diacetate. Results: PBE in a dose dependent manner significantly reduced acetic acid induced writhing response in mice (P < 0.001). In peritoneal exudates, PBE significantly inhibited AA induced generation of ROS, P < 0.01. Conclusions: The present study indicates that PBE has promising analgesic activity, worthy of future pharmacological consideration.
Item Type: | Article |
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Source: | Copyright of this article belongs to Wolters Kluwer. |
Keywords: | Analgesic; Arachidonic Acid; Pain; Reactive Oxygen Species; Writhing |
ID Code: | 111285 |
Deposited On: | 09 Mar 2018 11:49 |
Last Modified: | 09 Mar 2018 11:49 |
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