Hariprasad, Gururao ; Hariprasad, Roopa ; Kumar, Lalit ; Srinivasan, Alagiri ; Kola, Srujana ; Kaushik, Amit (2013) Apolipoprotein A1 as a potential biomarker in the ascitic fluid for the differentiation of advanced ovarian cancers Biomarkers, 18 (6). pp. 532-541. ISSN 1354-750X
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Official URL: http://www.tandfonline.com/doi/abs/10.3109/1354750...
Related URL: http://dx.doi.org/10.3109/1354750X.2013.822561
Abstract
Context: Primary ovarian cancer and ovarian metastasis from non-ovarian cancers in advanced stage are closely mimicking conditions whose therapeutics and prognosis are different. Objective: To identify biomarkers that can differentiate the two variants of advanced ovarian cancers. Methods: Gel-based proteomics and antibody-based assays were used to study the differentially expressed proteins in the ascitic fluid of fourteen patients with advanced ovarian cancers. Results: Programmed Cell Death 1-Ligand 2, apolipoprotein A1, apolipoprotein A4 and anti-human fas antibody are differentially expressed proteins. Conclusions: Apolipoprotein A1 with a 61.8?ng/ml cut-off is a potential biomarker with the best differentiating statistical parameters.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Taylor and Francis Group. |
| Keywords: | Gel-based Proteomics; Metastatic Ovarian Cancer; Primary Ovarian Cancer; Validation |
| ID Code: | 111210 |
| Deposited On: | 25 Sep 2017 12:42 |
| Last Modified: | 25 Sep 2017 12:42 |
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