Rajini Balakrishnan, A. ; Easwaran, K. R. K. (1983) CD and NMR studies on the aggregation of amphotericin-B in solution Biochimica et Biophysica Acta (BBA) - Biomembranes, 1148 (2). pp. 269-277. ISSN 0005-2736
Full text not available from this repository.
Official URL: http://linkinghub.elsevier.com/retrieve/pii/000527...
Related URL: http://dx.doi.org/10.1016/0005-2736(93)90139-Q
Abstract
We report in this paper the aggregation properties of amphotericin-B (amp-B) in solution using CD and 1H-NMR techniques. Our results indicate that the preferred structure of amp-B in dimethylsulfoxide is a monomer at low concentrations (10-4M and below) and a stable dimer at higher concentrations (range 5 · 103 M to 10-2M). In a DMSO/ethanol mixture (1:1 (v/v)), the antibiotic is monomeric, irrespective of the concentration within the range studied. We propose a head-to-tail model based on NMR data. An understanding of the head-to-tail dimer, is, we believe important, particularly in view of the recent report wherein it is proposed that the drug inserts into bilayers as head-to-tail oligomers.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Polyene Antifungal Antibiotic; NMR; 1H-; Circular Dichroism; Aggregation; Amphotericin B |
| ID Code: | 11119 |
| Deposited On: | 09 Nov 2010 03:56 |
| Last Modified: | 31 May 2011 09:11 |
Repository Staff Only: item control page
