Seetharama Jois, D. S. ; Suresh, Stephen ; Vijayan, M. ; Easwaran, K. R. K. (1996) NMR and X-ray crystallographic studies on cyclic tetrapeptide, cyclo (D-Phe-Pro-Sar-Gly) International Journal of Peptide and Protein Research, 48 (1). pp. 12-20. ISSN 0367-8377
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Official URL: http://onlinelibrary.wiley.com/doi/10.1111/j.1399-...
Related URL: http://dx.doi.org/10.1111/j.1399-3011.1996.tb01102.x
Abstract
The conformation of the synthetic cyclic tetrapeptide cyclo (D-Phe-Pro-Sar-Gly) has been determined in solution using the nuclear magnetic resonance technique and in the crystal state by X-ray crystallography. Results showed that the peptide exhibited two different conformations in solution, conformer 1 having cis-trans-cis-trans peptide bonds and conformer 2 having trans-cis-trans-cis peptide bonds. No intramolecular hydrogen bonds were observed in the structures. The X-ray diffraction studies showed the crystals to be orthorhombic with space group P212121 with unit-cell dimensions, a = 5.790, b= 10.344, c = 31.446 Å, Z=4, R= 0.104 for 2301 observed reflections. The crystal structure showed only one type of conformer having cis-trans-cis-trans peptide bonds similar to the conformer 1 in solution.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Munksgaard International Publishers. |
| Keywords: | Cyclic Tetrapeptide; Cis-trans Peptide Bonds; Ion-binding; Nuclear Magnetic Resonance |
| ID Code: | 11037 |
| Deposited On: | 08 Nov 2010 06:19 |
| Last Modified: | 31 May 2011 08:47 |
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