Mannose binding lectin gene variants and susceptibility to tuberculosis in HIV-1 infected patients of South India

Alagarasu, Kalichamy ; Selvaraj, Paramasivam ; Swaminathan, Soumya ; Raghavan, Sampathkumar ; Narendran, Gopalan ; Narayanan, Paranji R. (2007) Mannose binding lectin gene variants and susceptibility to tuberculosis in HIV-1 infected patients of South India Tuberculosis, 87 (6). pp. 535-543. ISSN 1472-9792

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Official URL: http://www.sciencedirect.com/science/article/pii/S...

Related URL: http://dx.doi.org/10.1016/j.tube.2007.07.007

Abstract

Mannose binding lectin (MBL) plays an important role in innate immunity. Plasma MBL levels and MBL2 gene polymorphisms were studied in HIV-1 infected patients without tuberculosis (HIV+TB−) (n = 151) and with tuberculosis (HIV+TB+) (n = 109), HIV negative tuberculosis patients (HIV−TB+) (n = 148) and healthy controls (n = 146) by ELISA and genotyping by polymerase chain reaction based methods. MBL levels were significantly increased among HIV−TB+ and HIV+TB+ patients than controls and HIV+TB− patients (P<0.05). A significantly increased frequency of OO genotype of structural polymorphism and YY genotype of −221Y/X was observed among HIV−TB+ patients than controls. In HIV+TB+ patients, a significantly increased frequency of YA/YA diplotype (associated with very high MBL levels) was observed compared to controls (P=0.03). In HIV+TB+ patients, a significantly decreased frequency of medium MBL expression diplotypes (XA/XA and YA/YO) were noticed compared to HIV+TB− and healthy controls. The results suggest that YA/YA diplotype associated with very high MBL levels may predispose HIV-infected patients to tuberculosis while O/O genotype associated with very low MBL levels may be associated with susceptibility to tuberculosis in HIV uninfected individuals. Medium MBL expression diplotypes might protect against development of TB in HIV-infected patients.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:MBL; HIV; HIV–TB; Tuberculosis; Gene Polymorphisms
ID Code:110191
Deposited On:01 Sep 2017 09:14
Last Modified:01 Sep 2017 09:14

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