Anti-tuberculosis drug resistance in patients with HIV and tuberculosis in South India

Swaminathan, S. ; Paramasivan, C. N. ; Ponnuraja, C. ; Iliayas, S. ; Rajasekaran, S. ; Narayanan, P. R. (2005) Anti-tuberculosis drug resistance in patients with HIV and tuberculosis in South India The International Journal of Tuberculosis and Lung Disease, 9 (8). pp. 896-900. ISSN 1027-3719

Full text not available from this repository.

Official URL: http://www.ingentaconnect.com/contentone/iuatld/ij...

Abstract

Setting: Tuberculosis Research Centre clinics at Chennai and Madurai, Tamil Nadu, South India. Objectives: To investigate the prevalence and pattern of drug resistance among patients with HIV and pulmonary tuberculosis (PTB). Design: Prospective cohort study of HIV-positive patients with PTB between January 2001 and May 2003. Sputum mycobacterial culture and drug susceptibility testing were performed. Results: A total of 204 patients with positive sputum cultures for Mycobacterium tuberculosis were included; 167 of them were new cases, and 37 had a history of previous anti-tuberculosis treatment for >1 month. Among the former, resistance to isoniazid (INH) was observed in 22 (13%) and MDR-TB in 7 (4.2%). Reported resistance rates in this geographic area among new cases ranged from 15% to 28% for INH and 2.8% to 3.4% for MDR (INH + rifampicin [RMP]). In contrast, among HIV-positive patients with a history of previous treatment, resistance was found to INH in 10 (27%) and to RMP in 7 (18.9%), while MDR-TB was seen in 5 (13.5%) patients. Conclusion: Among new TB patients, MDR-TB is marginally higher in HIV-positive patients than in the non-HIV-infected population in this region. Standard treatment guidelines should be followed. Higher rates of drug resistance are observed among previously treated patients.

Item Type:Article
Source:Copyright of this article belongs to The International Union Against Tuberculosis & Lung Disease.
Keywords:HIV; MDR-TB; Anti-tuberculosis Drug Resistance; Tuberculosis
ID Code:109891
Deposited On:01 Sep 2017 09:13
Last Modified:01 Sep 2017 09:13

Repository Staff Only: item control page