Varshney, Neha ; Schaekel, Alida ; Singha, Rima ; Chakraborty, Tanmoy ; van Wijlick, Lasse ; Ernst, Joachim F. ; Sanyal, Kaustuv (2015) A surprising role for the Sch9 protein kinase in chromosome segregation in Candida albicans Genetics, 199 (3). pp. 671-674. ISSN 0016-6731
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Official URL: http://www.genetics.org/content/199/3/671
Related URL: http://dx.doi.org/10.1534/genetics.114.173542
Abstract
The AGC kinase Sch9 regulates filamentation in Candida albicans. Here, we show that Sch9 binding is most enriched at the centromeres in C. albicans, but not in Saccharomyces cerevisiae. Deletion of CaSch9 leads to a 150- to 750-fold increase in chromosome loss. Thus, we report a previously unknown role of Sch9 in chromosome segregation.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Genetics Society of America. |
| Keywords: | Kinase; Sch9; Centromere; Chromosome Segregation; Kinetochore |
| ID Code: | 109884 |
| Deposited On: | 25 Oct 2017 13:09 |
| Last Modified: | 25 Oct 2017 13:09 |
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