Gurumurthy, Prema ; Ramachandran, Geetha ; Hemanth Kumar, A. K. ; Rajasekaran, S. ; Padmapriyadarsini, C. ; Swaminathan, Soumya ; Bhagavathy, S. ; Venkatesan, P. ; Sekar, L. ; Mahilmaran, A. ; Ravichandran, N. ; Paramesh, P. (2004) Decreased bioavailability of rifampin and other antituberculosis drugs in patients with advanced human immunodeficiency virus disease Antimicrobial Agents and Chemotherapy, 48 (11). pp. 4473-4475. ISSN 0066-4804
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Official URL: http://aac.asm.org/content/48/11/4473
Related URL: http://dx.doi.org/10.1128/AAC.48.11.4473-4475.2004
Abstract
We evaluated the effects of human immunodeficiency virus (HIV) disease on pharmacokinetics of antituberculosis medications by measuring concentrations of isoniazid and rifampin in blood and of pyrazinamide and ethambutol in urine. Peak concentration and exposure were reduced for rifampin, and rapid acetylators of isoniazid had lower drug levels. HIV and HIV-tuberculosis patients who have diarrhea and cryptosporidial infection exhibit decreased bioavailability of antituberculosis drugs.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Society for Microbiology. |
| ID Code: | 109871 |
| Deposited On: | 01 Sep 2017 09:02 |
| Last Modified: | 01 Sep 2017 09:02 |
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