Balasubramanian, S. V. ; Sikdar, S. K. ; Easwaran, K. R. K. (1992) Bilayers containing calcium ionophore A23187 form channels Biochemical and Biophysical Research Communications, 189 (2). pp. 1038-1042. ISSN 0006-291X
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/000629...
Related URL: http://dx.doi.org/10.1016/0006-291X(92)92308-K
Abstract
For the first time, based on bilayer membrane conductance experiments, it has been shown that A23187, a carboxylic calcium ionophore, incorporated in lipid bilayers gives single channel currents similar to the well known gramicidin channel. The current characteristics indicate the possibility that the transmembrane ion transport by this important calcium ionophore is initially by a carrier mechanism but with time is by a channel or pore mechanism due to the aggregation of the molecule in a lipid matrix.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 10987 |
| Deposited On: | 09 Nov 2010 04:20 |
| Last Modified: | 03 May 2012 05:14 |
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