Roy, S. ; Scherer, M. T. ; Briner, T. J. ; Smith, J. A. ; Gefter, M. L. (1989) Murine MHC polymorphism and T cell specificities Science, 244 (4904). pp. 572-575. ISSN 0036-8075
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Official URL: http://science.sciencemag.org/content/244/4904/572...
Related URL: http://dx.doi.org/10.1126/science.2470147
Abstract
The major histocompatibility complex (MHC) genes are polymorphic in mouse and man. The products of these genes are receptors for peptides, which while bound, are displayed to T lymphocytes. When bound peptides from antigens are recognized by T lymphocytes, an immune response is initiated against the antigens. This study assessed the relation of the polymorphic MHC molecules to their peptide specificity. The results indicate that although an individual of the species has a limited ability to recognize antigens, the species as a whole has broad reactivity. This rationalizes the extreme polymorphism observed.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Association for the Advancement of Science. |
| ID Code: | 109564 |
| Deposited On: | 31 Jan 2018 09:38 |
| Last Modified: | 31 Jan 2018 09:38 |
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