Risk of development of tuberculosis in HIV-infected patients

Swaminathan, S. ; Ramachandran, R. ; Baskaran, G. ; Paramasivan, C. N. ; Ramanathan, U. ; Venkatesan, P. ; Prabhakar, R. ; Datta, M. (2000) Risk of development of tuberculosis in HIV-infected patients International Journal of Tuberculosis and Lung Disease, 4 (9). pp. 839-44. ISSN 1027-3719

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Abstract

Objective: To estimate the rate of development of active tuberculosis (TB) in a cohort of human immunodeficiency virus (HIV) positive patients, and to identify the characteristics of these patients. Design: A total of 175 HIV-positive individuals were recruited from clinics for sexually transmitted diseases and followed up for 31 ± 6.8 months. Clinical examination, chest X-ray, sputum smear for acid-fast bacilli and culture for mycobacteria and HIV serology were performed at the time of registration and repeated periodically. Results: Seventeen patients had TB at intake and another 24 developed TB during follow-up, giving a breakdown rate of 6.9/100 person-years (p-y) (95% confidence interval [CI] 4.1–9.6). The attack rates were similar in tuberculin positive (7.1/100 p-y, 95%CI 3.4–10.8) and negative (6.7/100 p-y, 95%CI 2.6–10.8) patients. There was a trend towards higher mortality in patients who developed TB (10.5/100 p-y, 95%CI 4.8–15.2) compared to those who did not (6.1/100 p-y, 95%CI 3.2–8.8). Conclusions: The results of this study provide information regarding the high risk of development of active tuberculosis and its associated mortality in HIV-infected persons. The risk of developing TB appears to be equally high in tuberculin positive and negative individuals, suggesting that new infections could play a major role in this susceptible population.

Item Type:Article
Source:Copyright of this article belongs to International Union Against Tuberculosis and Lung Disease.
Keywords:HIV; Mortality; Tuberculin Reaction; Tuberculosis
ID Code:109379
Deposited On:01 Sep 2017 09:08
Last Modified:01 Sep 2017 09:08

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