Kolli, Rajesh ; Khanam, Saima ; Jain, Monika ; Ganju, Lilly ; Sai Ram, M. ; Khanna, Navin ; Swaminathan, S. (2006) A synthetic dengue virus antigen elicits enhanced antibody titers when linked to, but not mixed with, Mycobacterium tuberculosis HSP70 domain II Vaccine, 24 (22). pp. 4716-4726. ISSN 0264-410X
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.vaccine.2006.03.030
Abstract
Domain II of Mycobacterium tuberculosis (Mtb) heat shock protein 70 (HSP70), spanning amino acid residues 161–370, was covalently linked to a recently described synthetic dengue virus antigen to study the influence of the former on the immunogenicity of the latter. Using an enzyme-linked immunosorbent assay, dengue antigen-specific antibody titers elicited by the fusion protein in Balb/c mice were an order of magnitude higher than those elicited by either the synthetic dengue antigen alone or a physical mixture of the dengue antigen plus Mtb HSP70 domain II protein. Our data demonstrate that (i) Mtb HSP70 domain II is capable of potentiating B-cell response and (ii) it should be covalently linked to the target antigen to do so.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Mycobacterium Tuberculosis; Dengue Virus; HSP70; Immunodominant Epitopes; Immune Response |
| ID Code: | 109089 |
| Deposited On: | 09 Mar 2018 12:12 |
| Last Modified: | 09 Mar 2018 12:12 |
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