Bhatt, Prashant M. ; Azim, Yasser ; Thakur, Tejender S. ; Desiraju, Gautam R. (2009) Co-crystals of the anti-HIV drugs lamivudine and zidovudine Crystal Growth & Design, 9 (2). pp. 951-957. ISSN 1528-7483
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Official URL: http://pubs.acs.org/doi/abs/10.1021/cg8007359
Related URL: http://dx.doi.org/10.1021/cg8007359
Abstract
Co-crystal forming abilities of the two anti-HIV drugs lamivudine and zidovudine were studied. A study of five crystal structures was carried out to investigate the general applicability of the retrosynthetic approach in the design of new co-crystals. This analysis of co-crystals and salt structures showed a complete to partial success, and in one case, a total failure to obtain the predicted synthon. Both screening strategies and retrosynthetic methods may be appropriate for the discovery of new active pharmaceutical ingredients co-crystals.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 10902 |
| Deposited On: | 09 Nov 2010 04:33 |
| Last Modified: | 29 May 2011 15:46 |
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