Ghosh, Ruma Dey ; Banerjee, Kaushik ; Das, Satyajit ; Ganguly, Avishek ; Chakraborty, Paramita ; Sarkar, Avijit ; Chatterjee, Mitali ; Choudhuri, Soumitra K. (2013) A novel manganese complex, Mn-(II) N-(2-hydroxy acetophenone) glycinate overcomes multidrug-resistance in cancer European Journal of Pharmaceutical Sciences, 49 (4). pp. 737-747. ISSN 0928-0987
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.ejps.2013.05.002
Abstract
Multidrug resistance (MDR) remains a significant problem for effective cancer chemotherapy. In spite of considerable advances in drug discovery, most of the cancer cases still stay incurable because of resistance to chemotherapy. We synthesized a novel, Mn (II) complex (chelate), viz., manganese N-(2-hydroxy acetophenone) glycinate (MnNG) that exhibits considerable efficacy to overcome drug resistant cancer. The antiproliferative activity of MnNG was studied on doxorubicin resistant and sensitive human T lymphoblastic leukemia cells (CEM/ADR 5000 and CCRF/CEM). MnNG induced apoptosis significantly in CEM/ADR 5000 cells probably through generation of reactive oxygen species. Moreover, intraperitoneal (i.p.) application of MnNG at non-toxic doses caused significant increase in the life-span of Swiss albino mice bearing sensitive and doxorubicin resistant subline of Ehrlich ascites carcinoma cells.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Manganese Complex; Multidrug Resistance; Apoptosis; Leukemic Cells; Ehrlich Ascites Carcinoma |
| ID Code: | 108883 |
| Deposited On: | 09 Mar 2018 11:45 |
| Last Modified: | 09 Mar 2018 11:45 |
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