Lingaiah, B. P. Venkat ; Yakaiah, T. ; Shekhar, A. Chandra ; Kumar, A. Ravi ; Sathaiah, G. ; Raju, K. ; Rao, P. Shanthan ; Narsaiah, B. ; Kumar, K. Pranay ; Murthy, U. S. N. ; Purushotham, U. ; Sastry, G. Narahari (2012) Synthesis of novel alpha-amino acid functionalized 6-fluoro quinolones, their anti-bacterial activity and molecular docking studies Indian Journal of Chemistry (Section B), 51B (7). pp. 969-980. ISSN 0975-0983
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Abstract
A series of novel α-amino acid functionalized 6-fluoro quinolone derivatives have been synthesized from quinoline ester 2 in series of steps with good yields. The compounds have been screened against gram-positive and gram-negative bacteria in-vitro. Some compounds show promising activity against all species of gram-positive and gram-negative bacteria, with reference to standard Norfloxacin as well as Ciprofloxacin. The activity data is validated by molecular docking studies and are in good co-relation with observed trends.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to National Institute of Science Communication and Information Resources. |
| Keywords: | Quinolones; Aminoacids; Chlorofluoroaniline; Docking Studies; Antibacterial |
| ID Code: | 108529 |
| Deposited On: | 01 Feb 2018 11:48 |
| Last Modified: | 01 Feb 2018 11:48 |
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