Specific cleavage of DNA at CG sites by Co(III) and Ni(II) desferal complexes

Joshi, Rajendra R. ; Nagappa Ganesh, K. (1992) Specific cleavage of DNA at CG sites by Co(III) and Ni(II) desferal complexes FEBS Letters, 313 (3). pp. 303-306. ISSN 0014-5793

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/001457...

Related URL: http://dx.doi.org/10.1016/0014-5793(92)81215-8

Abstract

It is demonstrated that Co(III) and Ni(II) complexes of desferal, a siderophore chelating drug, show specificity for cleavage of DNA at CG sites, while the corresponding Cu(II) complex cleaves DNA sequences at both CG and AT sites.

Item Type:	Article
Source:	Copyright of this article belongs to Federation of European Biochemical Societies.
Keywords:	Desferal; DNA Cleavage; Sequence Specificity
ID Code:	10848
Deposited On:	09 Nov 2010 04:42
Last Modified:	16 May 2016 20:23

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