Rana, Vipul S. ; Kumar, Vaijayanti A. ; Ganesh, Krishna N. (1997) Oligonucleotides with (N-thymin-1-ylacetyl) 1-phenylserinol in backbone: chiral acyclic analogues that form DNA triplexes Bioorganic & Medicinal Chemistry Letters, 7 (22). pp. 2837-2842. ISSN 0960-894X
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S09608...
Related URL: http://dx.doi.org/10.1016/S0960-894X(97)10105-6
Abstract
The synthesis of oligonucleotides containing chiral acyclic 2(R/S)-(N-thymin-1-ylacetyl)-amino-1(R/S)-phenyl-1,3-propanediol unit in the backbone (l, R=Ar) is described. When used as third strand of a triplex with complementary natural duplex, the modified oligonucleotides form stable triplexes with triplex ↔ duplex transition Tm dependent on the number, position and stereochemistry of modification.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 10843 |
| Deposited On: | 09 Nov 2010 04:43 |
| Last Modified: | 31 May 2011 09:50 |
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