Prakash, T. P. ; Krishnakumar, R. ; Ganesh, K. N. (1993) Approaches to nuclease models: synthesis and conformational studies of dTprA conjugated with histamine AT C8(A) and ethylenediamine at C5'(T) Nucleosides, Nucleotides and Nucleic Acids, 12 (7). pp. 713-728. ISSN 1525-7770
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Official URL: http://www.informaworld.com/smpp/content~db=all~co...
Related URL: http://dx.doi.org/10.1080/07328319308021505
Abstract
Synthesis and spectroscopic characterization of a dinucleotide dTprA 2 having imidazole containing side chain at C8 of adenine and aminoethylamino side chain at C5' of nucleosugar is presented. Spectroscopic results suggest that such modifications do not drastically change the conformation of the new molecule relative to that of parent derivative. An anti glycosyl torsion would place the C8-conjugated histamine close to phosphate in right orientation for putative intramolecular interaction as in ribonuclease catalytic site.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Taylor and Francis Ltd. |
| ID Code: | 10825 |
| Deposited On: | 09 Nov 2010 04:46 |
| Last Modified: | 31 May 2011 10:00 |
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