Chakravarty, Rubel ; Shukla, Rakesh ; Ram, Ramu ; Venkatesh, Meera ; Tyagi, Avesh Kumar ; Dash, Ashutosh (2011) Exploitation of nano alumina for the chromatographic separation of clinical grade 188Re from 188W: a renaissance of the 188W/188Re generator technology Analytical Chemistry, 83 (16). pp. 6342-6348. ISSN 0003-2700
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Official URL: http://pubs.acs.org/doi/abs/10.1021/ac201232m
Related URL: http://dx.doi.org/10.1021/ac201232m
Abstract
The 188W/188Re generator using an acidic alumina column for chromatographic separation of 188Re has remained the most popular procedure world over. The capacity of bulk alumina for taking up tungstate ions is limited (∼50 mg W/g) necessitating the use of very high specific activity 188W (185–370 GBq/g), which can be produced only in very few high flux reactors available in the world. In this context, the use of high-capacity sorbents would not only mitigate the requirement of high specific activity 188W but also facilitate easy access to 188Re. A solid state mechanochemical approach to synthesize nanocrystalline γ-Al2O3 possessing very high W-sorption capacity (500 mg W/g) was developed. The structural and other investigations of the material were carried out using X-ray diffraction (XRD), transmission electron microscopy (TEM), Brunauer Emmett Teller (BET) surface area analysis, thermogravimetric-differential thermal analysis (TG-DTA), and dynamic light scattering (DLS) techniques. The synthesized material had an average crystallite size of ∼5 nm and surface area of 252 ± 10 m2/g. Sorption characteristics such as distribution ratios (Kd), capacity, breakthrough profile, and elution behavior were investigated to ensure quantitative uptake of 188W and selective elution of 188Re. A 11.1 GBq (300 mCi) 188W/188Re generator was developed using nanocrystalline γ-Al2O3, and its performance was evaluated for a period of 6 months. The overall yield of 188Re was >80%, with >99.999% radionuclidic purity and >99% radiochemical purity. The eluted 188Re possessed appreciably high radioactive concentration and was compatible for the preparation of 188Re labeled radiopharmaceuticals.
Item Type: | Article |
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Source: | Copyright of this article belongs to American Chemical Society. |
ID Code: | 108166 |
Deposited On: | 01 Feb 2018 11:33 |
Last Modified: | 01 Feb 2018 11:33 |
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