Govindaraju, T. ; Kumar, Vaijayanti A. ; Ganesh, Krishna N. (2005) (SR/RS)-cyclohexanyl PNAs: conformationally preorganized PNA analogues with unprecedented preference for duplex formation with RNA Journal of the American Chemical Society, 127 (12). pp. 4144-4145. ISSN 0002-7863
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Official URL: http://pubs.acs.org/doi/abs/10.1021/ja044142v
Related URL: http://dx.doi.org/10.1021/ja044142v
Abstract
PNA oligomers H-GTAGATCAT-lys-NH2 with cis-(1S,2R/1R,2S)-cyclohexyl-T (III) in the backbone form PNA:RNA duplexes with Tm~ 30-50°C higher than that of PNA:DNA duplexes. In comparison, cis-(1S,2R/1R,2S)-cyclopentyl PNA-T (IV) form highly stable duplexes with both RNA and DNA without discrimination.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 10795 |
| Deposited On: | 09 Nov 2010 04:52 |
| Last Modified: | 31 May 2011 09:35 |
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