Kamal, Ahmed ; Khan, M. Naseer ; Reddy, K. Srinivasa ; Rohini, K. ; Sastry, G. Narahari ; Sateesh, B. ; Sridhar, B. (2007) Synthesis, structure analysis, and antibacterial activity of some novel 10-substituted 2-(4-piperidyl/phenyl)-5,5-dioxo[1,2,4]triazolo[1,5-b][1,2,4]benzothiadiazine derivatives Bioorganic & Medicinal Chemistry Letters, 17 (19). pp. 5400-5405. ISSN 0960-894X
Full text not available from this repository.
Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.bmcl.2007.07.043
Abstract
A new series of 10-substituted 5,5-dioxo-5,10-dihydro[1,2,4]triazolo[1,5-b]-[1,2,4]benzothiadiazine arylsulfonamide derivatives (10a–j and 13a–f) was synthesized. The structures of these compounds were confirmed on the basis of spectral data, elemental analysis, X-ray analysis, and quantum chemical calculations. These compounds were evaluated for their efficacy as antibacterial agents against various Gram-positive and Gram-negative strains of bacteria. Amongst these compounds 10f and 10i were the most active compounds against Escherichia coli and 13e against E. coli as well as Bacillus subtilis. Moreover, other compounds also showed potent inhibitory activity in comparison to the standard drugs.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Triazolobenzothiadiazines; Aryl Sulfonamides; Antibacterial Activity; X-ray Crystallography; Quantum Chemical Calculations |
| ID Code: | 107881 |
| Deposited On: | 28 Jul 2017 06:13 |
| Last Modified: | 28 Jul 2017 06:13 |
Repository Staff Only: item control page
