Qureshi, Sameera Fatima ; Ali, Altaf ; Venkateshwari, Ananthapur ; Rao, Hygriv ; Jayakrishnan, M. P. ; Narasimhan, Calambur ; Shenthar, Jayaprakash ; Thangaraj, Kumarasamy ; Nallari, Pratibha (2014) Atrial natriuretic peptide gene-a potential biomarker for long QT syndrome EXCLI Journal, 13 . pp. 834-842. ISSN 1611-2156
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Official URL: http://www.excli.de/volume13.php
Abstract
This study highlights the possible implication of NPPA (Natriuretic Peptide Precursor A) gene in the etiology of Long QT Syndrome (LQTS) by population-based as well as familial study. Three SNPs of NPPA - C-664G, C1363A and T1766C were examined by molecular analyses in LQTS, controls and First Degree Relatives (FDRs). This study revealed a possible association of 1364 C>A SNP ‘C’ allele with LQTS (p = 0.0013). All three SNPs were in tight linkage disequilibrium. The familial study highlights the association of NPPA SNP with cLQTS and implicating it as a potential biomarker in South Indian population.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmun. |
| Keywords: | Atrial Natriuretic Peptide; Long QT Syndrome; Cardiogenesis; Biomarker; Polymorphisms |
| ID Code: | 107829 |
| Deposited On: | 02 Jul 2017 11:23 |
| Last Modified: | 02 Jul 2017 11:23 |
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