Barawkar, D. A. ; Ganesh, K. N. (1994) Exploring DNA minor groove interactions through a probe conjugate in major groove: fluorescence studies on netrosin complexation with dU-5-aminodansyl-DNA Biochemical and Biophysical Research Communications, 203 (1). pp. 53-58. ISSN 0006-291X
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00062...
Related URL: http://dx.doi.org/10.1006/bbrc.1994.2147
Abstract
The binding of netropsin to 5-Aminodansyl-dU-DNA (2-5) in minor groove is shown to correlate with fluorescence changes of dansyl fluorophore located in major groove. This enables a study of a minor groove binding event through crosstalk with conjugated probe in major groove. The dielectric constant of major groove estimated from fluorescence properties of (2-6) is about 55D in contrast to the literature reported minor groove dielectric constant of 20D in the poly[d(AT)]-poly[d(AT)] duplex.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 10777 |
| Deposited On: | 09 Nov 2010 04:56 |
| Last Modified: | 31 May 2011 09:57 |
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