Krishna, A. G. ; Balasubramanian, D. ; Ganesh, K. N. (1994) Sugar-DNA molecular recognition: specific interaction of α-1,4-glucopyranose chains with DNA in the minor groove Biochemical and Biophysical Research Communications, 202 (1). pp. 204-210. ISSN 0006-291X
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00062...
Related URL: http://dx.doi.org/10.1006/bbrc.1994.1913
Abstract
α(1,4) glucopyranose chains (dextrins) are shown to interact with DNA via hydrophobic interactions from the minor groove side, while α(1,6) dextrans do not bind DNA. The observed specific α(1,4) linked sugar-DNA interactions may have importance in recognition of DNA by ene-diyne class of antibiotics via their saccharide units which have mostly α(1,4) linkages.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 10776 |
| Deposited On: | 09 Nov 2010 04:56 |
| Last Modified: | 13 May 2011 07:31 |
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