Shamsi, Monis Bilal ; Govindaraj, Periyasamy ; Chawla, Latika ; Malhotra, Neena ; Singh, Neeta ; Mittal, Suneeta ; Talwar, Pankaj ; Thangaraj, Kumarasamy ; Dada, Rima (2013) Mitochondrial DNA variations in ova and blastocyst: implications in assisted reproduction Mitochondrion, 13 (2). pp. 96-105. ISSN 1567-7249
Full text not available from this repository.
Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.mito.2013.01.002
Abstract
Mitochondrial DNA (mtDNA) of oocyte is critical for its function, embryo quality and development. Analysis of complete mtDNA of 49 oocytes and 18 blastocysts from 67 females opting for IVF revealed 437 nucleotide variations. 40.29% samples had either disease associated or non-synonymous novel or pathogenic mutation in evolutionarily conserved regions. Samples with disease associated mtDNA mutations had low fertilization rate and poor embryo quality, however no difference in implantation or clinical pregnancy rate was observed. Screening mtDNA from oocyte/blastocyst is a simple, clinically reliable method for diagnostic evaluation of female infertility and may reduce risk of mtDNA disease transmission.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Oocyte; Blastocyst; Mitochondrial Diseases; In Vitro Fertilization; Female Infertility |
| ID Code: | 107576 |
| Deposited On: | 25 Jul 2017 11:23 |
| Last Modified: | 25 Jul 2017 11:23 |
Repository Staff Only: item control page
