C60-Fullerene binds with the ATP binding domain of human DNA topoiosmerase II alpha

Baweja, Lokesh ; Gurbani, Deepak ; Shanker, Rishi ; Pandey, Alok K. ; Subramanian, V. ; Dhawan, Alok (2011) C60-Fullerene binds with the ATP binding domain of human DNA topoiosmerase II alpha Journal of Biomedical Nanotechnology, 7 (1). pp. 177-178. ISSN 1550-7033

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Official URL: http://www.ingentaconnect.com/contentone/asp/jbn/2...

Related URL: http://dx.doi.org/10.1166/jbn.2011.1257

Abstract

C60-fullerene has promising biological applications, such as drug delivery, biosensors, diagnosis and theraupetics. Despite of these applications, several in vitro studies have also reported the DNA damaging potential of this nanomaterial. Though, very little is known about the mechanism involved behind the fullerene mediated DNA damage. Our study was aimed at identifying the binding site of fullerene in the ATP binding domain of human topoisomerase II alpha, a major enzyme involved in maintaining DNA topology. In silico studies of fullerene with the enzyme demonstrated that it can interact with the active site residues of this enzyme through hydrophobic, pi-stacking and van der Waals interactions and could inhibit the activity of this enzyme.

Item Type:Article
Source:Copyright of this article belongs to American Scientific Publishers.
Keywords:DNA Damage; Fullerenes; Human DNA Topoisomerase II Alpha; Nanomaterials
ID Code:107287
Deposited On:01 Dec 2017 12:30
Last Modified:01 Dec 2017 12:30

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